Version 5.4
Homo sapiens Gene: PHC1
Summary
InnateDB Gene IDBG-17468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHC1
Gene Name polyhomeotic homolog 1 (Drosophila)
Synonyms EDR1; HPH1; MCPH11; RAE28
Species Homo sapiens
Ensembl Gene ENSG00000111752
Encoded Proteins
IDBP-366281
polyhomeotic homolog 1 (Drosophila)
IDBP-585095
polyhomeotic homolog 1 (Drosophila)
IDBP-598490
polyhomeotic homolog 1 (Drosophila)
IDBP-602237
polyhomeotic homolog 1 (Drosophila)
IDBP-599607
polyhomeotic homolog 1 (Drosophila)
IDBP-596216
polyhomeotic homolog 1 (Drosophila)
IDBP-594140
polyhomeotic homolog 1 (Drosophila)
IDBP-586156
polyhomeotic homolog 1 (Drosophila)
IDBP-593822
polyhomeotic homolog 1 (Drosophila)
IDBP-599986
polyhomeotic homolog 1 (Drosophila)
IDBP-583344
polyhomeotic homolog 1 (Drosophila)
IDBP-586342
polyhomeotic homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8913896-8941467
Strand Forward strand
Band p13.31
Transcripts
ENST00000433083 ENSP00000399194
ENST00000433847
ENST00000538657 ENSP00000437654
ENST00000543824 ENSP00000440674
ENST00000544916 ENSP00000437659
ENST00000544539 ENSP00000437645
ENST00000539063 ENSP00000437459
ENST00000540574 ENSP00000444308
ENST00000541181 ENSP00000445939
ENST00000542346 ENSP00000446388
ENST00000539928
ENST00000537610 ENSP00000443676
ENST00000535510 ENSP00000445307
ENST00000540809
ENST00000536844 ENSP00000440488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016574 histone ubiquitination
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040669
View Gene Order
ENSBTAG00000018205
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.305985 Hs.524481 Hs.610270 Hs.685756 Hs.731517
RefSeq NM_001207024 NM_002355 XM_005253376 NM_004426 XM_005253334
HUGO
OMIM
CCDS CCDS73440 CCDS8598 CCDS8597
HPRD 16009
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca