Version 5.4
Bos taurus Gene: DUSP19
Summary
InnateDB Gene IDBG-639785.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP19
Gene Name dual specificity protein phosphatase 19
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020961
Encoded Proteins
IDBP-691973
dual specificity protein phosphatase 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162999:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:13503490-13519946
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027915 ENSBTAP00000027915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0008579 JUN kinase phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0007254 JNK cascade
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162999
View Gene Order
ENSMUSG00000027001
View Gene Order
Cross-References
SwissProt
TrEMBL A6H7A7
UniProt Splice Variant
Entrez Gene 505754
UniGene Bt.25075 Bt.96087
RefSeq NM_001098878
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146174 DAAA02004044
GenPept AAI46175
RNA Seq Atlas 505754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca