InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DUSP19

Summary

InnateDB Gene

IDBG-76931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP19

Gene Name

dual specificity phosphatase 19

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000162999

Encoded Proteins

IDBP-76933

dual specificity phosphatase 19

IDBP-76935

dual specificity phosphatase 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:183078559-183100005

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000354221	ENSP00000346160
ENST00000342619	ENSP00000343905
ENST00000469344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004860	protein kinase inhibitor activity
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008330	protein tyrosine/threonine phosphatase activity
GO:0008579	JUN kinase phosphatase activity
GO:0016791	phosphatase activity
GO:0030295	protein kinase activator activity
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0007254	JNK cascade
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043410	positive regulation of MAPK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0043508	negative regulation of JUN kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046329	negative regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027001

View Gene Order

ENSBTAG00000020961

Not yet available

Cross-References

SwissProt

Q8WTR2

TrEMBL

UniProt Splice Variant

Entrez Gene

142679

UniGene

Hs.132237

RefSeq

NM_001142314 NM_080876

HUGO

HGNC:18894

OMIM

611437

CCDS

CCDS2289 CCDS46469

HPRD

IMGT

EMBL

AB038770 AB063186 AB063187 AC064871 AF486808 AK314078 BC035000 BC093958 BC112005

GenPept

AAH35000 AAH93958 AAI12006 AAO49450 AAY24197 BAB82499 BAB83498 BAB83499 BAG36776

RNA Seq Atlas

142679