Version 5.4
Bos taurus Gene: PCNA
Summary
InnateDB Gene IDBG-639822.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCNA
Gene Name Proliferating cell nuclear antigen
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006065
Encoded Proteins
IDBP-692016
Proliferating cell nuclear antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:47788530-47794602
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007967 ENSBTAP00000007967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030337 DNA polymerase processivity factor activity
GO:0030971 receptor tyrosine kinase binding
GO:0032139 dinucleotide insertion or deletion binding
GO:0032405 MutLalpha complex binding
GO:0042802 identical protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006260 DNA replication
GO:0006272 leading strand elongation
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 cellular response to DNA damage stimulus
GO:0019985 translesion synthesis
GO:0030855 epithelial cell differentiation
GO:0032077 positive regulation of deoxyribonuclease activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030896 checkpoint clamp complex
GO:0043596 nuclear replication fork
GO:0043626 PCNA complex
GO:0070062 extracellular vesicular exosome
GO:0070557 PCNA-p21 complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_226948
G0 and Early G1 pathway
REACT_225014
S Phase pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_217593
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_209654
Extension of Telomeres pathway
REACT_227775
Transcription-coupled NER (TC-NER) pathway
REACT_222852
Removal of the Flap Intermediate from the C-strand pathway
REACT_213604
DNA Replication pathway
REACT_221747
Telomere Maintenance pathway
REACT_221748
Polymerase switching on the C-strand of the telomere pathway
REACT_211609
G1/S Transition pathway
REACT_214597
Leading Strand Synthesis pathway
REACT_237773
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_204980
Resolution of Abasic Sites (AP sites) pathway
REACT_206699
Removal of the Flap Intermediate pathway
REACT_212448
Nucleotide Excision Repair pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214477
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_222458
Global Genomic NER (GG-NER) pathway
REACT_202907
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_201998
E2F mediated regulation of DNA replication pathway
REACT_221571
Processive synthesis on the lagging strand pathway
REACT_205725
Processive synthesis on the C-strand of the telomere pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_204262
DNA Repair pathway
REACT_233731
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_214081
Lagging Strand Synthesis pathway
REACT_235284
Mismatch Repair pathway
REACT_227100
Removal of DNA patch containing abasic residue pathway
REACT_202612
Base Excision Repair pathway
REACT_227796
Chromosome Maintenance pathway
REACT_225533
G1/S-Specific Transcription pathway
REACT_222741
Polymerase switching pathway
REACT_207824
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_218453
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_212930
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_203054
DNA strand elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3ZBW4
TrEMBL
UniProt Splice Variant
Entrez Gene 515499
UniGene Bt.52764
RefSeq NM_001034494
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103068
GenPept AAI03069
RNA Seq Atlas 515499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca