Bos taurus Protein: PCNA | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-692016.2 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | PCNA | ||||||||||||||||||||
Protein Name | Proliferating cell nuclear antigen | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||
Ensembl Protein | ENSBTAP00000007967 | ||||||||||||||||||||
InnateDB Gene | IDBG-639822 (PCNA) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). {ECO:0000250}. | ||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents (By similarity). {ECO:0000250}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000730
Proliferating cell nuclear antigen, PCNA IPR007268 Rad9/Ddc1 IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminal IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminal |
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PFAM |
PF04139
PF00705 PF02747 |
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PRINTS |
PR00339
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PIRSF | |||||||||||||||||||||
SMART | |||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q3ZBW4 | ||||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 515499 | ||||||||||||||||||||
UniGene | Bt.52764 | ||||||||||||||||||||
RefSeq | NP_001029666 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | |||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | BC103068 | ||||||||||||||||||||
GenPept | AAI03069 | ||||||||||||||||||||