Version 5.4
| Bos taurus Gene: CD163 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-639861.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CD163 | ||||||||
| Gene Name | Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 | ||||||||
| Synonyms | M130 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000019669 | ||||||||
| Encoded Proteins |
Scavenger receptor cysteine-rich type 1 protein M130Soluble CD163
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177575:
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:102245937-102278444 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging of heme from plasma pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TWEAK pathway
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| REACTOME |
Scavenging of heme from plasma pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging of heme from plasma pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | P85521 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 533844 | ||||||||
| UniGene | Bt.6915 | ||||||||
| RefSeq | NM_001163413 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AAFC03037181 AAFC03037182 GQ184570 | ||||||||
| GenPept | ACS87934 | ||||||||
| RNA Seq Atlas | 533844 | ||||||||