Version 5.4
Homo sapiens Gene: CD163
Summary
InnateDB Gene IDBG-16292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD163
Gene Name CD163 molecule
Synonyms M130; MM130
Species Homo sapiens
Ensembl Gene ENSG00000177575
Encoded Proteins
IDBP-16294
CD163 molecule
IDBP-237109
CD163 molecule
IDBP-365655
CD163 molecule
IDBP-587668
CD163 molecule
IDBP-593000
CD163 molecule
IDBP-593764
CD163 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:7470813-7503893
Strand Reverse strand
Band p13.31
Transcripts
ENST00000359156 ENSP00000352071
ENST00000396620 ENSP00000379863
ENST00000432237 ENSP00000403885
ENST00000537044
ENST00000542705
ENST00000534848
ENST00000542280 ENSP00000445438
ENST00000537626 ENSP00000439226
ENST00000541972 ENSP00000444071
ENST00000538840
ENST00000539632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006953 acute-phase response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030666 endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008845
View Gene Order
ENSBTAG00000019669
Not yet available
Pathways
NETPATH
NetPath_26
TWEAK pathway
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9332
UniGene Hs.504641 Hs.735678
RefSeq NM_004244 NM_203416 XM_005253528 XM_005253529
HUGO HGNC:1631
OMIM 605545
CCDS CCDS53742 CCDS8578
HPRD 05708
IMGT
EMBL
GenPept
RNA Seq Atlas 9332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca