InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.21055

Summary

InnateDB Gene

IDBG-639894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.21055

Gene Name

MAP kinase-interacting serine/threonine-protein kinase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019933

Encoded Proteins

IDBP-692104

MAP kinase-interacting serine/threonine-protein kinase 1

IDBP-692106

MAP kinase-interacting serine/threonine-protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21149447

[Homo sapiens] MKNK1 plays an important role in IFNG induced IRF1 expression and is essential for generation of anti-proliferative responses.

PMID 21149447

[Mus musculus] Mknk1 plays an important role in Ifng induced Irf1 expression and is essential for generation of anti-proliferation responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079277:
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:100126262-100172587

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026556	ENSBTAP00000026556
ENSBTAT00000026554	ENSBTAP00000026554

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009651	response to salt stress
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand