InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.62821

Summary

InnateDB Gene

IDBG-639904.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.62821

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006615

Encoded Proteins

IDBP-692109

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18667412

[Homo sapiens] CASP7 is a substrate of the CASP1 inflammasomes, demonstrating the existence of a nucleotide binding and oligomerization domain-like receptor/CASP1/CASP7 cascade and the existence of distinct activation mechanisms for CASP3 and CASP7 in response to microbial stimuli and bacterial infection.

PMID 19343209

[Homo sapiens] CASP7 activation by the NLRC4 inflammasome restricts Legionella pneumophila infection in mice.

PMID 22807671

[Homo sapiens] Host activation of CASP7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection. (Demonstrated in mice)

PMID 22807671

[Mus musculus] Host activation of Casp7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165806:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:34457100-34464840

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008706

ENSBTAP00000008706

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007507	heart development
GO:0009411	response to UV
GO:0016485	protein processing
GO:0043525	positive regulation of neuron apoptotic process
GO:0097194	execution phase of apoptosis