Version 5.4
Homo sapiens Gene: CASP7
Summary
InnateDB Gene IDBG-90066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP7
Gene Name caspase 7, apoptosis-related cysteine peptidase
Synonyms CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Species Homo sapiens
Ensembl Gene ENSG00000165806
Encoded Proteins
IDBP-90068
caspase 7, apoptosis-related cysteine peptidase
IDBP-90070
caspase 7, apoptosis-related cysteine peptidase
IDBP-90074
caspase 7, apoptosis-related cysteine peptidase
IDBP-90076
caspase 7, apoptosis-related cysteine peptidase
IDBP-90080
caspase 7, apoptosis-related cysteine peptidase
IDBP-385663
caspase 7, apoptosis-related cysteine peptidase
IDBP-385676
caspase 7, apoptosis-related cysteine peptidase
IDBP-807281
caspase 7, apoptosis-related cysteine peptidase
IDBP-807285
caspase 7, apoptosis-related cysteine peptidase
IDBP-807286
caspase 7, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18667412
CASP7 is a substrate of the CASP1 inflammasomes, demonstrating the existence of a nucleotide binding and oligomerization domain-like receptor/CASP1/CASP7 cascade and the existence of distinct activation mechanisms for CASP3 and CASP7 in response to microbial stimuli and bacterial infection.
PMID 19343209
CASP7 activation by the NLRC4 inflammasome restricts Legionella pneumophila infection in mice.
PMID 22807671
Host activation of CASP7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22807671
[Mus musculus] Host activation of Casp7 in response to pore formation during Listeria monocytogene infection represents an adaptive mechanism by which host cells can protect membrane integrity during infection.
Entrez Gene
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:113679162-113730907
Strand Forward strand
Band q25.3
Transcripts
ENST00000369331 ENSP00000358337
ENST00000369321 ENSP00000358327
ENST00000345633 ENSP00000298701
ENST00000369318 ENSP00000358324
ENST00000369315 ENSP00000358321
ENST00000429617 ENSP00000400094
ENST00000452490 ENSP00000398107
ENST00000468790
ENST00000487232
ENST00000614447 ENSP00000478285
ENST00000621607 ENSP00000478999
ENST00000621345 ENSP00000480584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 94 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007507 heart development
GO:0007568 aging
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 response to UV
GO:0016485 protein processing
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025076
View Gene Order
ENSBTAG00000006615
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
REACTOME
REACT_1767
SMAC-mediated dissociation of IAP:caspase complexes pathway
REACT_2190
SMAC binds to IAPs pathway
REACT_607
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_666
SMAC-mediated apoptotic response pathway
REACT_578
Apoptosis pathway
REACT_963
Apoptotic factor-mediated response pathway
REACT_831
Cytochrome c-mediated apoptotic response pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
e2f_pathway
E2F transcription factor network
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt P55210
TrEMBL Q5SVL2
UniProt Splice Variant
Entrez Gene 840
UniGene Hs.732924 Hs.742363 Hs.9216
RefSeq NM_001227 NM_001267056 NM_001267057 NM_001267058 NM_033338 NM_033339 NM_033340 XM_006718016 XM_006718017 XM_006718018 XM_006718019
HUGO HGNC:1508
OMIM 601761
CCDS CCDS7581 CCDS58096 CCDS73200 CCDS7580 CCDS7582
HPRD 03457
IMGT
EMBL AB451281 AB451413 AK298964 AL592546 AL627395 BC015799 BT006683 CH471066 U37448 U37449 U39613 U40281 U67206 U67319 U67320
GenPept AAC50303 AAC50304 AAC50346 AAC50352 AAC51152 AAC51153 AAF21460 AAH15799 AAP35329 BAG61059 BAG70095 BAG70227 CAI12638 CAI12639 CAI16004 CAI16005 EAW49494 EAW49495 EAW49496 EAW49497 EAW49498
RNA Seq Atlas 840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca