Version 5.4
Bos taurus Gene: ADRA1D
Summary
InnateDB Gene IDBG-639995.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRA1D
Gene Name alpha-1D adrenergic receptor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019504
Encoded Proteins
IDBP-692196
adrenergic, alpha-1D-, receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171873:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51370890-51392113
Strand Forward strand
Band
Transcripts
ENSBTAT00000025981 ENSBTAP00000025981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004937 alpha1-adrenergic receptor activity
Biological Process
GO:0001986 negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0071875 adrenergic receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171873
View Gene Order
ENSMUSG00000027335
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_16927
Adrenoceptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04970
Salivary secretion pathway
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B7W0
UniProt Splice Variant
Entrez Gene 539543
UniGene Bt.63500
RefSeq NM_001205684
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036171
GenPept
RNA Seq Atlas 539543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca