InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adra1d

Summary

InnateDB Gene

IDBG-207140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra1d

Gene Name

adrenergic receptor, alpha 1d

Synonyms

[a]1d; Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8; Spr8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027335

Encoded Proteins

IDBP-207144

adrenergic receptor, alpha 1d

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171873:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:131545850-131562283

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103184

ENSMUSP00000099473

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity

Biological Process

GO:0001986	negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0071875	adrenergic receptor signaling pathway