InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACLY

Summary

InnateDB Gene

IDBG-640080.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACLY

Gene Name

ATP-citrate synthase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016740

Encoded Proteins

IDBP-692300

ATP-citrate synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131473:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:42691369-42735634

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022258

ENSBTAP00000022258

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0046872	metal ion binding
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037	cofactor binding