InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acly

Summary

InnateDB Gene

IDBG-211434.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acly

Gene Name

ATP citrate lyase

Synonyms

A730098H14Rik; AW538652

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020917

Encoded Proteins

IDBP-211438

ATP citrate lyase

IDBP-266773

ATP citrate lyase

IDBP-266777

ATP citrate lyase

IDBP-626408

ATP citrate lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131473:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100476353-100528000

Strand

Reverse strand

Band

Transcripts

ENSMUST00000007131	ENSMUSP00000007131
ENSMUST00000107389	ENSMUSP00000103012
ENSMUST00000107385	ENSMUSP00000103008
ENSMUST00000154151
ENSMUST00000152969
ENSMUST00000154888
ENSMUST00000165111	ENSMUSP00000127632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037	cofactor binding

Biological Process

GO:0006085	acetyl-CoA biosynthetic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0044262	cellular carbohydrate metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome