Bos taurus Gene: HIP1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-640092.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | HIP1 | ||||||||||||||
Gene Name | huntingtin-interacting protein 1 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000000781 | ||||||||||||||
Encoded Proteins |
huntingtin interacting protein 1
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127946:
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington\'s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 25:34393880-34528240 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME | |||||||||||||||
KEGG |
Huntington's disease pathway
Huntington's disease pathway
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INOH | |||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | F1MWF0 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 505919 | ||||||||||||||
UniGene | Bt.57461 | ||||||||||||||
RefSeq | NM_001192078 XM_005225025 XM_005225026 XM_005225027 | ||||||||||||||
HUGO | HGNC:4913 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02058198 DAAA02058199 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 505919 | ||||||||||||||