InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hip1

Summary

InnateDB Gene

IDBG-203840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hip1

Gene Name

huntingtin interacting protein 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039959

Encoded Proteins

IDBP-203842

huntingtin interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127946:
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington\'s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135406523-135545122

Strand

Reverse strand

Band

Transcripts

ENSMUST00000060311

ENSMUSP00000059033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030276	clathrin binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048268	clathrin coat assembly
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000127946

View Gene Order

ENSBTAG00000000781

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05016

Huntington's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa05016

Huntington's disease pathway

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

Q8VD75

TrEMBL

UniProt Splice Variant

Entrez Gene

215114

UniGene

Mm.280805

RefSeq

NM_146001 XM_006504413 XM_006504415

OMIM

CCDS

CCDS51663

HPRD

IMGT

MGI ID

MGI:1099804

MGI Symbol

Hip1

EMBL

AK166346 AK220182 BC017516

GenPept

AAH17516 BAD90367 BAE38720

RNA Seq Atlas

215114