InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MED27

Summary

InnateDB Gene

IDBG-640125.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED27

Gene Name

Mediator of RNA polymerase II transcription subunit 27

Synonyms

CRSP8

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000382

Encoded Proteins

IDBP-692351

Mediator of RNA polymerase II transcription subunit 27

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160563:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101977235-102196459

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000493

ENSBTAP00000000493

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0019827	stem cell maintenance