InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED27

Summary

InnateDB Gene

IDBG-90181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED27

Gene Name

mediator complex subunit 27

Synonyms

CRAP34; CRSP34; CRSP8; TRAP37

Species

Homo sapiens

Ensembl Gene

ENSG00000160563

Encoded Proteins

IDBP-90185

mediator complex subunit 27

IDBP-90189

mediator complex subunit 27

IDBP-809954

mediator complex subunit 27

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:131860107-132079908

Strand

Reverse strand

Band

q34.13

Transcripts

ENST00000357028	ENSP00000349530
ENST00000292035	ENSP00000292035
ENST00000474263	ENSP00000477136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance