Version 5.4
Bos taurus Gene: PTPN6
Summary
InnateDB Gene IDBG-640141.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN6
Gene Name tyrosine-protein phosphatase non-receptor type 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020294
Encoded Proteins
IDBP-692367
tyrosine-protein phosphatase non-receptor type 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 9520455
[Homo sapiens] PTPN6 (SHP-1) normally functions to antagonize the IL-2 signal transduction pathway and human T-lymphotropic virus type I (HTLV-I) infection and oncogenic transformation can lead to loss of SHP-1 expression, resulting in constitutive activation of IL-2 regulated T cell responses.
PMID 8524272
[Homo sapiens] PTPN6 reversibly associates with the IFN-alpha receptor complex upon IFN stimulation and selectively regulates distinct components of JAK/STAT signal transduction pathways.
PMID 17079228
[Homo sapiens] PTPN6 specifically downregulates MAP3K7 (TAK1) through dephosphorylation, suppressing inflammatory responses via TAK1 signalling pathways.
PMID 18391954
[Homo sapiens] PTPN6 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
PMID 20145200
[Homo sapiens] PTPN6 tyrosine phosphatase activity plays a critical role in induction of IL2B production in macrophages in response to TLR ligands.
PMID 25876760
[Mus musculus] Bordetella pertussis CyaA toxin plays a role in evading nitric oxide-mediated killing in macrophages through a cAMP-dependent activation of the Ptpn6 phosphatase.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111679:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:103862679-103872171
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027046 ENSBTAP00000027046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470 protein dephosphorylation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030220 platelet formation
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0035855 megakaryocyte development
GO:0042130 negative regulation of T cell proliferation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0045577 regulation of B cell differentiation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050853 B cell receptor signaling pathway
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0042105 alpha-beta T cell receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111679
View Gene Order
ENSMUSG00000004266
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_24980
Regulation of IFNG signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
REACT_263643
PD-1 signaling pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_215628
Signal regulatory protein (SIRP) family interactions pathway
REACT_198645
Regulation of IFNG signaling pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_229531
Adaptive Immune System pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_198627
Regulation of IFNA signaling pathway
REACT_198622
Interferon alpha/beta signaling pathway
REACT_223082
Cell-Cell communication pathway
KEGG
hsa04520
Adherens junction pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05140
Leishmaniasis pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04520
Adherens junction pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05140
Leishmaniasis pathway
INOH
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
epopathway
EPO signaling pathway
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
il4_2pathway
IL4-mediated signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL A5D980
UniProt Splice Variant
Entrez Gene 512312
UniGene
RefSeq NM_001098017 XM_005207130 XM_005207131
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT030499 DAAA02014453
GenPept ABQ12939
RNA Seq Atlas 512312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca