Version 5.4
Bos taurus Protein: PTPN6
Summary
InnateDB Protein IDBP-692367.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN6
Protein Name tyrosine-protein phosphatase non-receptor type 6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027046
InnateDB Gene IDBG-640141 (PTPN6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470 protein dephosphorylation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030220 platelet formation
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0035855 megakaryocyte development
GO:0042130 negative regulation of T cell proliferation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0045577 regulation of B cell differentiation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050853 B cell receptor signaling pathway
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0042105 alpha-beta T cell receptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000980 SH2 domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00017
PF14633
PRINTS PR00700
PR00401
PIRSF PIRSF000929
SMART SM00194
SM00252
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D980
UniProt Splice Variant
Entrez Gene 512312
UniGene
RefSeq NP_001091486
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT030499 DAAA02014453
GenPept ABQ12939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca