InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HSPB1

Summary

InnateDB Gene

IDBG-640144.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPB1

Gene Name

heat shock protein beta-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011969

Encoded Proteins

IDBP-692369

heat shock protein beta-1

IDBP-692373

heat shock protein beta-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106211:
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:34858435-34861074

Strand

Forward strand

Band

Transcripts

ENSBTAT00000044397	ENSBTAP00000041898
ENSBTAT00000015883	ENSBTAP00000015883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.

Predicted by orthology
Total	93 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001895	retina homeostasis
GO:0006469	negative regulation of protein kinase activity
GO:0006950	response to stress
GO:0009615	response to virus
GO:0032731	positive regulation of interleukin-1 beta production
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028	positive regulation of endothelial cell chemotaxis
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030018	Z disc
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome