Version 5.4
Bos taurus Protein: HSPB1
Summary
InnateDB Protein IDBP-692373.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB1
Protein Name heat shock protein beta-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015883
InnateDB Gene IDBG-640144 (HSPB1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008426 protein kinase C inhibitor activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001895 retina homeostasis
GO:0006469 negative regulation of protein kinase activity
GO:0009615 response to virus
GO:0032731 positive regulation of interleukin-1 beta production
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone
PFAM PF00011
PRINTS PR00299
PIRSF PIRSF036514
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BEL7
UniProt Splice Variant
Entrez Gene 516099
UniGene
RefSeq NP_001020740
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058204 DAAA02058205
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca