Version 5.4
Bos taurus Gene: ZP3
Summary
InnateDB Gene IDBG-640156.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZP3
Gene Name zona pellucida sperm-binding protein 3
Synonyms Zp-3; Zp-3B
Species Bos taurus
Ensembl Gene ENSBTAG00000014834
Encoded Proteins
IDBP-692389
zona pellucida sperm-binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188372:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:34960635-34968376
Strand Forward strand
Band
Transcripts
ENSBTAT00000019756 ENSBTAP00000019756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0005515 protein binding
Biological Process
GO:0001809 positive regulation of type IV hypersensitivity
GO:0001825 blastocyst formation
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002687 positive regulation of leukocyte migration
GO:0006828 manganese ion transport
GO:0006886 intracellular protein transport
GO:0007339 binding of sperm to zona pellucida
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0032729 positive regulation of interferon-gamma production
GO:0032753 positive regulation of interleukin-4 production
GO:0035556 intracellular signal transduction
GO:0035803 egg coat formation
GO:0042102 positive regulation of T cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048599 oocyte development
GO:0050729 positive regulation of inflammatory response
GO:0051897 positive regulation of protein kinase B signaling
GO:0071421 manganese ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:2000344 positive regulation of acrosome reaction
GO:2000386 positive regulation of ovarian follicle development
GO:2000388 positive regulation of antral ovarian follicle growth
Cellular Component
GO:0002081 outer acrosomal membrane
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0030141 secretory granule
GO:0031012 extracellular matrix
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000188372
View Gene Order
ENSMUSG00000004948
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
REACT_199082
Fertilization pathway
REACT_199085
Reproduction pathway
REACT_199072
Interaction With The Zona Pellucida pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6H6X7 E5FYE1 Q58DI4
UniProt Splice Variant
Entrez Gene 280964
UniGene Bt.511
RefSeq NM_173974
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146035 BT021613 DAAA02058207 HM631687 HM631690
GenPept AAI46036 AAX46460 ADQ47437 ADQ47440
RNA Seq Atlas 280964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca