InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZP3

Summary

InnateDB Gene

IDBG-23247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP3

Gene Name

zona pellucida glycoprotein 3 (sperm receptor)

Synonyms

Zp-3; ZP3A; ZP3B; ZPC

Species

Homo sapiens

Ensembl Gene

ENSG00000188372

Encoded Proteins

IDBP-23249

zona pellucida glycoprotein 3 (sperm receptor)

IDBP-240731

zona pellucida glycoprotein 3 (sperm receptor)

IDBP-240733

zona pellucida glycoprotein 3 (sperm receptor)

IDBP-379770

zona pellucida glycoprotein 3 (sperm receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:76397518-76442071

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000336517	ENSP00000337310
ENST00000394860	ENSP00000378329
ENST00000394857	ENSP00000378326
ENST00000416245	ENSP00000411955
ENST00000466960
ENST00000479793
ENST00000467555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0030246	carbohydrate binding
GO:0032190	acrosin binding

Biological Process

GO:0001809	positive regulation of type IV hypersensitivity
GO:0001825	blastocyst formation
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0002687	positive regulation of leukocyte migration
GO:0002922	positive regulation of humoral immune response
GO:0006828	manganese ion transport
GO:0006886	intracellular protein transport
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0032504	multicellular organism reproduction
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0035803	egg coat formation
GO:0042102	positive regulation of T cell proliferation
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048599	oocyte development
GO:0050729	positive regulation of inflammatory response
GO:0051897	positive regulation of protein kinase B signaling
GO:0070528	protein kinase C signaling
GO:0070588	calcium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport
GO:0090280	positive regulation of calcium ion import
GO:2000344	positive regulation of acrosome reaction
GO:2000360	negative regulation of binding of sperm to zona pellucida
GO:2000368	positive regulation of acrosomal vesicle exocytosis
GO:2000386	positive regulation of ovarian follicle development
GO:2000388	positive regulation of antral ovarian follicle growth

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002081	outer acrosomal membrane
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004948

View Gene Order

ENSBTAG00000014834

Not yet available

Pathways

NETPATH

REACTOME

REACT_163933

Interaction With The Zona Pellucida pathway

REACT_163914

Fertilization pathway

REACT_163848

Reproduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.656137

RefSeq

NM_001110354 NM_007155

HUGO

OMIM

CCDS

CCDS47618 CCDS5586

HPRD

01690

IMGT

EMBL

GenPept

RNA Seq Atlas