Version 5.4
Bos taurus Gene: USP5
Summary
InnateDB Gene IDBG-640200.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP5
Gene Name ubiquitin carboxyl-terminal hydrolase 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019780
Encoded Proteins
IDBP-692431
ubiquitin specific peptidase 5 (isopeptidase T)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111667:
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:103946733-103960262
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026356 ENSBTAP00000026356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108 protein K48-linked deubiquitination
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111667
View Gene Order
ENSMUSG00000038429
View Gene Order
Cross-References
SwissProt
TrEMBL F1N3P2
UniProt Splice Variant
Entrez Gene 505280
UniGene
RefSeq NM_001192056 XM_005207110
HUGO HGNC:12628
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014455
GenPept
RNA Seq Atlas 505280

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca