Version 5.4
Homo sapiens Gene: USP5
Summary
InnateDB Gene IDBG-15267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP5
Gene Name ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms ISOT
Species Homo sapiens
Ensembl Gene ENSG00000111667
Encoded Proteins
IDBP-15269
ubiquitin specific peptidase 5 (isopeptidase T)
IDBP-15273
ubiquitin specific peptidase 5 (isopeptidase T)
IDBP-600905
ubiquitin specific peptidase 5 (isopeptidase T)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6852128-6866632
Strand Forward strand
Band p13.31
Transcripts
ENST00000229268 ENSP00000229268
ENST00000389231 ENSP00000373883
ENST00000542087 ENSP00000444668
ENST00000535080
ENST00000537267
ENST00000541969
ENST00000542371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 73 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005764 lysosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038429
View Gene Order
ENSBTAG00000019780
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631661
RefSeq NM_001098536 NM_003481
HUGO
OMIM
CCDS CCDS31733 CCDS41743
HPRD 03265
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca