Bos taurus Gene: CNTNAP1
Summary
InnateDB Gene IDBG-640336.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTNAP1
Gene Name contactin-associated protein 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019097
Encoded Proteins
contactin associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108797:
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for \'contactin-associated protein,\' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43380114-43394478
Strand Forward strand
Band
Transcripts
ENSBTAT00000025424 ENSBTAP00000025424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002175 protein localization to paranode region of axon
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0008088 axon cargo transport
GO:0019227 neuronal action potential propagation
GO:0030913 paranodal junction assembly
GO:0031175 neuron projection development
GO:0048812 neuron projection morphogenesis
GO:0050884 neuromuscular process controlling posture
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0033270 paranode region of axon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Neurofascin interactions pathway
L1CAM interactions pathway
Developmental Biology pathway
Axon guidance pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
Neurofascin interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.46498
RefSeq NM_001206895 XM_005220746 XM_005220747
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas