Version 5.4
Homo sapiens Gene: CNTNAP1
Summary
InnateDB Gene IDBG-51437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTNAP1
Gene Name contactin associated protein 1
Synonyms CASPR; CNTNAP; NRXN4; P190
Species Homo sapiens
Ensembl Gene ENSG00000108797
Encoded Proteins
IDBP-51441
contactin associated protein 1
IDBP-764556
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for \'contactin-associated protein,\' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42682613-42699814
Strand Forward strand
Band q21.2
Transcripts
ENST00000264638 ENSP00000264638
ENST00000586801
ENST00000585534
ENST00000591662 ENSP00000466571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0002175 protein localization to paranode region of axon
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0008088 axon cargo transport
GO:0009967 positive regulation of signal transduction
GO:0019227 neuronal action potential propagation
GO:0030913 paranodal junction assembly
GO:0031175 neuron projection development
GO:0048812 neuron projection morphogenesis
GO:0050884 neuromuscular process controlling posture
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0033270 paranode region of axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017167
View Gene Order
ENSBTAG00000019097
Not yet available
Pathways
NETPATH
REACTOME
REACT_22312
Neurofascin interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408730
RefSeq NM_003632 XM_005257748 XM_006722141 XM_006722142
HUGO
OMIM
CCDS CCDS11436
HPRD 03825
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca