InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLOD3

Summary

InnateDB Gene

IDBG-640370.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLOD3

Gene Name

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000342

Encoded Proteins

IDBP-692634

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106397:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:36057472-36065405

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000447

ENSBTAP00000000447

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding
GO:0033823	procollagen glucosyltransferase activity
GO:0051213	dioxygenase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001886	endothelial cell morphogenesis
GO:0008104	protein localization
GO:0021915	neural tube development
GO:0030199	collagen fibril organization
GO:0042311	vasodilation
GO:0048730	epidermis morphogenesis
GO:0055114	oxidation-reduction process
GO:0060425	lung morphogenesis
GO:0070831	basement membrane assembly