Version 5.4
Bos taurus Gene: LHB
Summary
InnateDB Gene IDBG-640379.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHB
Gene Name Lutropin subunit beta
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000038735
Encoded Proteins
IDBP-692637
Lutropin subunit beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104826:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56026310-56027284
Strand Reverse strand
Band
Transcripts
ENSBTAT00000057054 ENSBTAP00000048635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0030823 regulation of cGMP metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104826
View Gene Order
ENSMUSG00000038194
View Gene Order
Pathways
NETPATH
REACTOME
REACT_210701
Peptide hormone metabolism pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_218655
Glycoprotein hormones pathway
REACT_214353
Signal Transduction pathway
REACT_220432
Peptide hormone biosynthesis pathway
REACT_213782
Metabolism of proteins pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_227794
Mineralocorticoid biosynthesis pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_210620
Hormone ligand-binding receptors pathway
REACT_212422
Androgen biosynthesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16942
Hormone ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15398
Glycoprotein hormones pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_11047
Mineralocorticoid biosynthesis pathway
REACT_11059
Androgen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P04651
TrEMBL
UniProt Splice Variant
Entrez Gene 786429
UniGene Bt.12926
RefSeq NM_173930 XM_001787202 XM_005219147
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL M10077 M11506
GenPept AAA30623 AAB59267
RNA Seq Atlas 280839 786429
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca