Version 5.4
Bos taurus Gene: BT.65578
Summary
InnateDB Gene IDBG-640385.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.65578
Gene Name BAG family molecular chaperone regulator 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013641
Encoded Proteins
IDBP-692642
BAG family molecular chaperone regulator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151929:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:40118556-40141989
Strand Forward strand
Band
Transcripts
ENSBTAT00000018131 ENSBTAP00000018131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0051087 chaperone binding
Biological Process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0050821 protein stabilization
GO:0071260 cellular response to mechanical stimulus
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151929
View Gene Order
ENSMUSG00000030847
View Gene Order
Cross-References
SwissProt
TrEMBL F1MIU2
UniProt Splice Variant
Entrez Gene 782633
UniGene Bt.65578
RefSeq NM_001082471 XM_005225793
HUGO HGNC:939
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02059401
GenPept
RNA Seq Atlas 782633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca