InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FGFR2

Summary

InnateDB Gene

IDBG-640434.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFR2

Gene Name

fibroblast growth factor receptor 2

Synonyms

FGFR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014064

Encoded Proteins

IDBP-692740

FGFR2 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066468:
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:41823653-41926635

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018708

ENSBTAP00000018708

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003148	outflow tract septum morphogenesis
GO:0003149	membranous septum morphogenesis
GO:0006468	protein phosphorylation
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007528	neuromuscular junction development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0009791	post-embryonic development
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010453	regulation of cell fate commitment
GO:0010518	positive regulation of phospholipase activity
GO:0016310	phosphorylation
GO:0016331	morphogenesis of embryonic epithelium
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022612	gland morphogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0030324	lung development
GO:0030855	epithelial cell differentiation
GO:0030901	midbrain development
GO:0030916	otic vesicle formation
GO:0031069	hair follicle morphogenesis
GO:0032808	lacrimal gland development
GO:0035264	multicellular organism growth
GO:0035265	organ growth
GO:0040014	regulation of multicellular organism growth
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0042476	odontogenesis
GO:0043410	positive regulation of MAPK cascade
GO:0045165	cell fate commitment
GO:0045839	negative regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048286	lung alveolus development
GO:0048489	synaptic vesicle transport
GO:0048557	embryonic digestive tract morphogenesis
GO:0048562	embryonic organ morphogenesis
GO:0048565	digestive tract development
GO:0048568	embryonic organ development
GO:0048608	reproductive structure development
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048730	epidermis morphogenesis
GO:0048755	branching morphogenesis of a nerve
GO:0048762	mesenchymal cell differentiation
GO:0050673	epithelial cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060174	limb bud formation
GO:0060348	bone development
GO:0060349	bone morphogenesis
GO:0060365	coronal suture morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060449	bud elongation involved in lung branching
GO:0060463	lung lobe morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512	prostate gland morphogenesis
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601	lateral sprouting from an epithelium
GO:0060615	mammary gland bud formation
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667	branch elongation involved in salivary gland morphogenesis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060688	regulation of morphogenesis of a branching structure
GO:0060915	mesenchymal cell differentiation involved in lung development
GO:0060916	mesenchymal cell proliferation involved in lung development
GO:0061031	endodermal digestive tract morphogenesis
GO:0070307	lens fiber cell development
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0043231	intracellular membrane-bounded organelle