Version 5.4
Bos taurus Protein: FGFR2
Summary
InnateDB Protein IDBP-692740.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFR2
Protein Name FGFR2 protein
Synonyms FGFR;
Species Bos taurus
Ensembl Protein ENSBTAP00000018708
InnateDB Gene IDBG-640434 (FGFR2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0006468 protein phosphorylation
GO:0007267 cell-cell signaling
GO:0007409 axonogenesis
GO:0007528 neuromuscular junction development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008589 regulation of smoothened signaling pathway
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009887 organ morphogenesis
GO:0010453 regulation of cell fate commitment
GO:0010518 positive regulation of phospholipase activity
GO:0016310 phosphorylation
GO:0016331 morphogenesis of embryonic epithelium
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022612 gland morphogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0030855 epithelial cell differentiation
GO:0030901 midbrain development
GO:0030916 otic vesicle formation
GO:0031069 hair follicle morphogenesis
GO:0032808 lacrimal gland development
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0040014 regulation of multicellular organism growth
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0043410 positive regulation of MAPK cascade
GO:0045165 cell fate commitment
GO:0045839 negative regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048286 lung alveolus development
GO:0048489 synaptic vesicle transport
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048730 epidermis morphogenesis
GO:0048755 branching morphogenesis of a nerve
GO:0048762 mesenchymal cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060174 limb bud formation
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060365 coronal suture morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060463 lung lobe morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 prostate gland morphogenesis
GO:0060523 prostate epithelial cord elongation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 lateral sprouting from an epithelium
GO:0060615 mammary gland bud formation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0061031 endodermal digestive tract morphogenesis
GO:0070307 lens fiber cell development
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PF00047
PRINTS PR00109
PIRSF PIRSF000628
SMART SM00220
SM00408
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q95KV2
UniProt Splice Variant
Entrez Gene 404193
UniGene
RefSeq NP_001192239
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ413268 AY642853 BC151652 DAAA02059441 Z68150
GenPept AAI51653 AAV34170 CAA92275 CAC88758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca