InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GAPDH

Summary

InnateDB Gene

IDBG-640457.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAPDH

Gene Name

Glyceraldehyde-3-phosphate dehydrogenase

Synonyms

GAPD

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014731

Encoded Proteins

IDBP-692721

Glyceraldehyde-3-phosphate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111640:
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104237902-104241979

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000037753

ENSBTAP00000037577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	136 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740	transferase activity
GO:0035605	peptidyl-cysteine S-nitrosylase activity
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006417	regulation of translation
GO:0006915	apoptotic process
GO:0035606	peptidyl-cysteine S-trans-nitrosylation
GO:0050821	protein stabilization
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process