Bos taurus Gene: G6PC
Summary
InnateDB Gene IDBG-640507.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G6PC
Gene Name Glucose-6-phosphatase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010184
Encoded Proteins
Glucose-6-phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131482:
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43590846-43601632
Strand Forward strand
Band
Transcripts
ENSBTAT00000013436 ENSBTAP00000013436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004346 glucose-6-phosphatase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0016787 hydrolase activity
GO:0042301 phosphate ion binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
GO:0006094 gluconeogenesis
GO:0006641 triglyceride metabolic process
GO:0008202 steroid metabolic process
GO:0010468 regulation of gene expression
GO:0015760 glucose-6-phosphate transport
GO:0016311 dephosphorylation
GO:0035264 multicellular organism growth
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0046415 urate metabolic process
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Metabolism of carbohydrates pathway
SLC-mediated transmembrane transport pathway
Hexose transport pathway
Myoclonic epilepsy of Lafora pathway
Transmembrane transport of small molecules pathway
Glucose transport pathway
Glycogen storage diseases pathway
Metabolism pathway
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Glucose transport pathway
Hexose transport pathway
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
Disease pathway
SLC-mediated transmembrane transport pathway
Metabolism pathway
Glucose transport pathway
Transmembrane transport of small molecules pathway
Hexose transport pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Galactose metabolism pathway
Glycolysis / Gluconeogenesis pathway
Insulin signaling pathway pathway
Starch and sucrose metabolism pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Insulin signaling pathway pathway
Glycolysis / Gluconeogenesis pathway
Starch and sucrose metabolism pathway
Galactose metabolism pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
INOH
Glycolysis Gluconeogenesis pathway
PID NCI
FOXA2 and FOXA3 transcription factor networks
FoxO family signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.17113
RefSeq NM_001076124
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas