InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: G6PC

Summary

InnateDB Protein

IDBP-692775.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6PC

Protein Name

Glucose-6-phosphatase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013436

InnateDB Gene

IDBG-640507 (G6PC)

Protein Structure

UniProt Annotation

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004346	glucose-6-phosphatase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0016787	hydrolase activity
GO:0042301	phosphate ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006094	gluconeogenesis
GO:0006641	triglyceride metabolic process
GO:0008202	steroid metabolic process
GO:0010468	regulation of gene expression
GO:0015760	glucose-6-phosphate transport
GO:0016311	dephosphorylation
GO:0035264	multicellular organism growth
GO:0042593	glucose homeostasis
GO:0042632	cholesterol homeostasis
GO:0046415	urate metabolic process
GO:0051156	glucose 6-phosphate metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
IPR016275 Glucose-6-phosphatase

PFAM

PF01569

PRINTS

PIRSF

PIRSF000905

SMART

SM00014

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q29RU6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538710

UniGene

Bt.17113

RefSeq

NP_001069592

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114011

GenPept

AAI14012