InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SP3

Summary

InnateDB Gene

IDBG-640536.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000176

Encoded Proteins

IDBP-692814

Sp3 transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172845:
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:22841314-22888725

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000201

ENSBTAP00000000201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001779	natural killer cell differentiation
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030224	monocyte differentiation
GO:0030324	lung development
GO:0030851	granulocyte differentiation
GO:0043353	enucleate erythrocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000172845

View Gene Order

ENSMUSG00000027109

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_22

Leptin pathway

REACTOME

KEGG

INOH

PID NCI

telomerasepathway

Regulation of Telomerase

Cross-References

SwissProt

TrEMBL

F1MCN2

UniProt Splice Variant

Entrez Gene

540766

UniGene

RefSeq

XM_002685296 XM_613036

HUGO

HGNC:11208

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02004207

GenPept

RNA Seq Atlas

540766