Version 5.4
Mus musculus Gene: Sp3
Summary
InnateDB Gene IDBG-179756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp3
Gene Name trans-acting transcription factor 3
Synonyms D130027J01Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000027109
Encoded Proteins
IDBP-179758
trans-acting transcription factor 3
IDBP-179760
trans-acting transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:72936427-72980446
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000102689 ENSMUSP00000099750
ENSMUST00000066003 ENSMUSP00000065807
ENSMUST00000133615
ENSMUST00000129565
ENSMUST00000141372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 13 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001779 natural killer cell differentiation
GO:0001829 trophectodermal cell differentiation
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030224 monocyte differentiation
GO:0030324 lung development
GO:0030851 granulocyte differentiation
GO:0043353 enucleate erythrocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060136 embryonic process involved in female pregnancy
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172845
View Gene Order
ENSBTAG00000000176
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
KEGG
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt O70494
TrEMBL Q2M4I5
UniProt Splice Variant
Entrez Gene 20687
UniGene Mm.124328 Mm.397782 Mm.465887
RefSeq NM_001018042 NM_001098425
OMIM
CCDS CCDS16122
HPRD
IMGT
MGI ID MGI:1277166
MGI Symbol Sp3
EMBL AF062567 AK004607 AK132702 AL844840 AY902330 BC027797 BC079874
GenPept AAC16322 AAH27797 AAH79874 AAX90615 BAC25090 BAE21310 CAM21417
RNA Seq Atlas 20687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca