InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.55601

Summary

InnateDB Gene

IDBG-640550.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.55601

Gene Name

mitogen-activated protein kinase kinase kinase MLT

Synonyms

MRK

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001083

Encoded Proteins

IDBP-692837

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091436:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:23443013-23608298

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000038527

ENSBTAP00000038340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007257	activation of JUN kinase activity
GO:0009314	response to radiation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process