InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: B230120H23Rik

Summary

InnateDB Gene

IDBG-179557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B230120H23Rik

Gene Name

RIKEN cDNA B230120H23 gene

Synonyms

AV006891; B230120H23Rik; MLTK; MLTKalpha; MLTKbeta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004085

Encoded Proteins

IDBP-179559

RIKEN cDNA B230120H23 gene

IDBP-535127

RIKEN cDNA B230120H23 gene

IDBP-535117

RIKEN cDNA B230120H23 gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091436:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:72285637-72442610

Strand

Forward strand

Band

Transcripts

ENSMUST00000090824	ENSMUSP00000088334
ENSMUST00000112073
ENSMUST00000135469	ENSMUSP00000118983
ENSMUST00000150126
ENSMUST00000135204
ENSMUST00000144111	ENSMUSP00000119340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007257	activation of JUN kinase activity
GO:0009314	response to radiation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000091436

View Gene Order

ENSBTAG00000001083

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

mmu04010

MAPK signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04530

Tight junction pathway

INOH

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.314618 Mm.479393

RefSeq

NM_001164791 NM_023057 XM_006499997

OMIM

CCDS

CCDS38143 CCDS50605

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas