Version 5.4
Bos taurus Gene: CAPN7
Summary
InnateDB Gene IDBG-640618.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN7
Gene Name calpain-7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006479
Encoded Proteins
IDBP-692922
calpain 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131375:
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153971502-154021605
Strand Forward strand
Band
Transcripts
ENSBTAT00000008495 ENSBTAP00000008495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0090541 MIT domain binding
Biological Process
GO:0006508 proteolysis
GO:0010634 positive regulation of epithelial cell migration
GO:0097264 self proteolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131375
View Gene Order
ENSMUSG00000021893
View Gene Order
Cross-References
SwissProt
TrEMBL E1BIX3
UniProt Splice Variant
Entrez Gene 618048
UniGene Bt.59677
RefSeq NM_001193181
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003685 DAAA02003686 DAAA02003687
GenPept
RNA Seq Atlas 618048

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca