Version 5.4
Homo sapiens Gene: CAPN7
Summary
InnateDB Gene IDBG-20624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN7
Gene Name calpain 7
Synonyms CALPAIN7; PALBH
Species Homo sapiens
Ensembl Gene ENSG00000131375
Encoded Proteins
IDBP-20626
calpain 7
IDBP-365955
calpain 7
IDBP-365958
calpain 7
IDBP-366012
calpain 7
IDBP-366017
calpain 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:15206152-15252918
Strand Forward strand
Band p25.1
Transcripts
ENST00000253693 ENSP00000253693
ENST00000418994 ENSP00000415482
ENST00000457023 ENSP00000389786
ENST00000415565 ENSP00000399486
ENST00000443567 ENSP00000394708
ENST00000463417
ENST00000472400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0090541 MIT domain binding
Biological Process
GO:0006508 proteolysis
GO:0010634 positive regulation of epithelial cell migration
GO:0097264 self proteolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021893
View Gene Order
ENSBTAG00000006479
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595234 Hs.665932 Hs.721007
RefSeq NM_014296 XM_006713080
HUGO
OMIM
CCDS CCDS2624
HPRD 05908
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca