InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GAD1

Summary

InnateDB Gene

IDBG-640815.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAD1

Gene Name

Glutamate decarboxylase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007258

Encoded Proteins

IDBP-693127

Glutamate decarboxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128683:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:25646775-25685832

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009547

ENSBTAP00000009547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004351	glutamate decarboxylase activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0008152	metabolic process
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process