InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRRAP

Summary

InnateDB Gene

IDBG-640887.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRRAP

Gene Name

transformation/transcription domain-associated protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007113

Encoded Proteins

IDBP-693207

transformation/transcription domain-associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196367:
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:37807383-37895047

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009365

ENSBTAP00000009365

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007093	mitotic cell cycle checkpoint
GO:0016578	histone deubiquitination
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0035267	NuA4 histone acetyltransferase complex