InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRRAP

Summary

InnateDB Gene

IDBG-28698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRRAP

Gene Name

transformation/transcription domain-associated protein

Synonyms

PAF350/400; PAF400; STAF40; TR-AP; Tra1

Species

Homo sapiens

Ensembl Gene

ENSG00000196367

Encoded Proteins

IDBP-28700

transformation/transcription domain-associated protein

IDBP-28702

transformation/transcription domain-associated protein

IDBP-382618

transformation/transcription domain-associated protein

IDBP-382635

transformation/transcription domain-associated protein

IDBP-382647

transformation/transcription domain-associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:98877933-99013243

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000355540	ENSP00000347733
ENST00000359863	ENSP00000352925
ENST00000417523	ENSP00000401107
ENST00000446306	ENSP00000403708
ENST00000456197	ENSP00000394645
ENST00000480695

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	104 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007093	mitotic cell cycle checkpoint
GO:0008152	metabolic process
GO:0016573	histone acetylation
GO:0016578	histone deubiquitination
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000125	PCAF complex
GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0035267	NuA4 histone acetyltransferase complex