Version 5.4
Bos taurus Gene: UROS
Summary
InnateDB Gene IDBG-640910.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UROS
Gene Name uroporphyrinogen-III synthase
Synonyms UROIIIS
Species Bos taurus
Ensembl Gene ENSBTAG00000005791
Encoded Proteins
IDBP-693215
uroporphyrinogen III synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188690:
The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]
The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther\'s disease). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:45635844-45660024
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007615 ENSBTAP00000007615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004852 uroporphyrinogen-III synthase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006780 uroporphyrinogen III biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000188690
View Gene Order
ENSMUSG00000030979
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_203298
Heme biosynthesis pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001191369 XM_005225856
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca