Version 5.4
Mus musculus Gene: Uros
Summary
InnateDB Gene IDBG-211247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uros
Gene Name uroporphyrinogen III synthase
Synonyms AI415298; UROIIIS; Uros3
Species Mus musculus
Ensembl Gene ENSMUSG00000030979
Encoded Proteins
IDBP-211249
uroporphyrinogen III synthase
IDBP-269376
uroporphyrinogen III synthase
IDBP-269378
uroporphyrinogen III synthase
IDBP-269380
uroporphyrinogen III synthase
IDBP-535229
uroporphyrinogen III synthase
IDBP-537670
uroporphyrinogen III synthase
IDBP-542327
uroporphyrinogen III synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:133686243-133710072
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000033276 ENSMUSP00000033276
ENSMUST00000106146 ENSMUSP00000101752
ENSMUST00000106145 ENSMUSP00000101751
ENSMUST00000106144 ENSMUSP00000101750
ENSMUST00000135760
ENSMUST00000144789
ENSMUST00000153698 ENSMUSP00000117187
ENSMUST00000124759 ENSMUSP00000119179
ENSMUST00000151348 ENSMUSP00000121763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004852 uroporphyrinogen-III synthase activity
GO:0048037 cofactor binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006780 uroporphyrinogen III biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
GO:0046677 response to antibiotic
GO:0071243 cellular response to arsenic-containing substance
GO:0071418 cellular response to amine stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188690
View Gene Order
ENSBTAG00000005791
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_203298
Heme biosynthesis pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9PYC9 E9Q8N3 E9Q9B5 Q3TPL3 Q9CW78 Q9JLU5
UniProt Splice Variant
Entrez Gene 22276
UniGene Mm.3160 Mm.407149
RefSeq XM_006507584 NM_009479 XM_006507580 XM_006507581 XM_006507582
OMIM
CCDS CCDS21934
HPRD
IMGT
MGI ID MGI:98917
MGI Symbol Uros
EMBL AC127348 AF133258 AK002971 AK164297 CH466531
GenPept AAF29593 BAB22486 BAE37723 EDL17771
RNA Seq Atlas 22276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca