InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADH7

Summary

InnateDB Gene

IDBG-640946.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH7

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015729

Encoded Proteins

IDBP-693250

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

IDBP-693252

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196344:
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:26547268-26562417

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064428	ENSBTAP00000055659
ENSBTAT00000020879	ENSBTAP00000020879

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004024	alcohol dehydrogenase activity, zinc-dependent
GO:0004031	aldehyde oxidase activity
GO:0004745	retinol dehydrogenase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0019841	retinol binding
GO:0035276	ethanol binding
GO:0046872	metal ion binding
GO:0048019	receptor antagonist activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006068	ethanol catabolic process
GO:0006069	ethanol oxidation
GO:0009617	response to bacterium
GO:0010430	fatty acid omega-oxidation
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0045471	response to ethanol
GO:0055114	oxidation-reduction process
GO:1900116	extracellular negative regulation of signal transduction