Version 5.4
Homo sapiens Gene: ADH7
Summary
InnateDB Gene IDBG-31333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH7
Gene Name alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Synonyms ADH4
Species Homo sapiens
Ensembl Gene ENSG00000196344
Encoded Proteins
IDBP-31335
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
IDBP-374826
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
IDBP-480718
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
IDBP-484900
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
IDBP-478647
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99412261-99435737
Strand Reverse strand
Band q23
Transcripts
ENST00000209665 ENSP00000209665
ENST00000437033 ENSP00000414254
ENST00000482593 ENSP00000420613
ENST00000485660
ENST00000476959 ENSP00000420269
ENST00000474027 ENSP00000420300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0004031 aldehyde oxidase activity
GO:0004745 retinol dehydrogenase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019841 retinol binding
GO:0035276 ethanol binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006068 ethanol catabolic process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0009617 response to bacterium
GO:0010430 fatty acid omega-oxidation
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0055114 oxidation-reduction process
GO:1900116 extracellular negative regulation of signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055301
View Gene Order
ENSBTAG00000015729
Not yet available
Pathways
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00830
Retinol metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00350
Tyrosine metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JP14
UniProt Splice Variant
Entrez Gene 131
UniGene Hs.389 Hs.622106
RefSeq NM_000673 NM_001166504
HUGO HGNC:256
OMIM 600086
CCDS CCDS34034 CCDS54781
HPRD 02515
IMGT
EMBL AP001960
GenPept
RNA Seq Atlas 131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca