Version 5.4
| Bos taurus Gene: ITGA2B | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-640964.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | ITGA2B | ||||||||||||
| Gene Name | integrin alpha-IIb | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000008165 | ||||||||||||
| Encoded Proteins |
integrin alpha-IIb
integrin alpha-IIb
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005961:
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 19:44798081-44811145 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Integrin cell surface interactions pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
Developmental Biology pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Signal Transduction pathway
ECM proteoglycans pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Integrin cell surface interactions pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
Developmental Biology pathway
ECM proteoglycans pathway
p130Cas linkage to MAPK signaling for integrins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
Hematopoietic cell lineage pathway
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Hypertrophic cardiomyopathy (HCM) pathway
Pathways in cancer pathway
Dilated cardiomyopathy pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Small cell lung cancer pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Pathways in cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
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| INOH |
Integrin signaling pathway pathway
Integrin signaling pathway pathway
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| PID NCI |
Integrin family cell surface interactions
Signaling events mediated by PTP1B
Ephrin B reverse signaling
Beta3 integrin cell surface interactions
Arf6 signaling events
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | A6QLB3 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 515011 | ||||||||||||
| UniGene | Bt.25495 | ||||||||||||
| RefSeq | XM_005220859 NM_001014929 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC147903 DAAA02049249 | ||||||||||||
| GenPept | AAI47904 | ||||||||||||
| RNA Seq Atlas | 515011 | ||||||||||||